Expression of intra-tumoral necrosis-associated cytokine pattern correlated with prognosis and immune status in glioma

Intra-tumoral necrosis (ITN) is reported to be an independent prognostic factor in glioma. However, knowledge of ITN mainly limited pseudopalisadwe, while its other aspects were neglected. Therefore, a deeper understanding could valuable for exact role The only reliable model was time-dependently achieved with the GL261 syngeneic mouse model. ITN-associated expression pattern enriched from RNA sequencing. TCGA glioma samples clustered into high-expression group (HEG) and low-expression (LEG) based on their association prognosis, clinical status, immune therapeutic responsiveness compared. Mouse demonstrated invasive histology. Cytokine signaling significantly necrotic compared non-necrotic tissues. Nine pro-inflammatory (IL6, PPBP, IL1A, TNFSF11, CXCL11, CXCL9, CXCL10, CXCL3, CCL8) two anti-inflammatory cytokine (IL1RN IL10) genes found related patterns. Comparative analysis showed that HEG had shorter survival time, five differentially distributed statuses, more infiltrated cells, greater checkpoints, better than LEG. In conclusion, characteristically expressed might indicate missed histology diagnosis. Its predict tumor grade, patients.